E-ISSN 2149-2018
 

Original Research 


Design and characterization of microsponge loaded controlled release epicutaneous gel of lornoxicam

Purnima Panday, Neha Shukla, Dharmesh Sisodiya, Vikas Jain, Suresh Chand Mahajan.

Abstract
Aim: Transdermal delivery, a successful novel approach aimed at achieving systematically active level of drug. The work involves the drug lornoxicam is a non-steroidal anti-inflammatory drug bearing analgesic, antiinflammatory, and antipyretic property. The micro sponge technology used to facilitate the controlled release of active drug into the skin in order to reduce the systematic exposure and minimize local cutaneous reactions of active drugs. The main objective of this work was to design and evaluate the gel formation of microsponge entrapped lornoxicam to increase the effectiveness of the treatment. Materials and Methods: The microsponges were prepared by quasi emulsion solvent diffusion method. The internal phase consisting eudragit RS-100 and ethyl cellulose dissolved in dichloromethane and ethyl alcohol, drug is slowly added to polymer solution with continuous stirring for 4 h, and then mixture was filtered to separate the microsponges. Microsponges was characterized by parameters like scanning electron microscopy, drug content, particle size analysis, compatibility studies using differential scanning calorimetry. Microsponge-loaded gel was characterized by physical parameters of gel, measurement of PH, viscosity study, Drug content study, in-vitro release studies using first order kinetics, Higuchi Model, Peppas release Model. Results: The different kinetics models showed that the release data followed Higuchi matrix and the release mechanism from microsponges was diffusion. Conclusion: From the results, it can be concluded that LMF3 formulation shows drug release in a controlled manner.

Key words: Epicutaneous gel, lornoxicam, microsponges


 
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How to Cite this Article
Pubmed Style

Purnima Panday, Neha Shukla, Dharmesh Sisodiya, Vikas Jain, Suresh Chand Mahajan. Design and characterization of microsponge loaded controlled release epicutaneous gel of lornoxicam. Appl Med Res. 2015; 1(1): 16-21. doi:10.5455/amr.20150127052147


Web Style

Purnima Panday, Neha Shukla, Dharmesh Sisodiya, Vikas Jain, Suresh Chand Mahajan. Design and characterization of microsponge loaded controlled release epicutaneous gel of lornoxicam. http://www.ejmamr.com/?mno=177594 [Access: December 15, 2018]. doi:10.5455/amr.20150127052147


AMA (American Medical Association) Style

Purnima Panday, Neha Shukla, Dharmesh Sisodiya, Vikas Jain, Suresh Chand Mahajan. Design and characterization of microsponge loaded controlled release epicutaneous gel of lornoxicam. Appl Med Res. 2015; 1(1): 16-21. doi:10.5455/amr.20150127052147



Vancouver/ICMJE Style

Purnima Panday, Neha Shukla, Dharmesh Sisodiya, Vikas Jain, Suresh Chand Mahajan. Design and characterization of microsponge loaded controlled release epicutaneous gel of lornoxicam. Appl Med Res. (2015), [cited December 15, 2018]; 1(1): 16-21. doi:10.5455/amr.20150127052147



Harvard Style

Purnima Panday, Neha Shukla, Dharmesh Sisodiya, Vikas Jain, Suresh Chand Mahajan (2015) Design and characterization of microsponge loaded controlled release epicutaneous gel of lornoxicam. Appl Med Res, 1 (1), 16-21. doi:10.5455/amr.20150127052147



Turabian Style

Purnima Panday, Neha Shukla, Dharmesh Sisodiya, Vikas Jain, Suresh Chand Mahajan. 2015. Design and characterization of microsponge loaded controlled release epicutaneous gel of lornoxicam. Applied Medical Research, 1 (1), 16-21. doi:10.5455/amr.20150127052147



Chicago Style

Purnima Panday, Neha Shukla, Dharmesh Sisodiya, Vikas Jain, Suresh Chand Mahajan. "Design and characterization of microsponge loaded controlled release epicutaneous gel of lornoxicam." Applied Medical Research 1 (2015), 16-21. doi:10.5455/amr.20150127052147



MLA (The Modern Language Association) Style

Purnima Panday, Neha Shukla, Dharmesh Sisodiya, Vikas Jain, Suresh Chand Mahajan. "Design and characterization of microsponge loaded controlled release epicutaneous gel of lornoxicam." Applied Medical Research 1.1 (2015), 16-21. Print. doi:10.5455/amr.20150127052147



APA (American Psychological Association) Style

Purnima Panday, Neha Shukla, Dharmesh Sisodiya, Vikas Jain, Suresh Chand Mahajan (2015) Design and characterization of microsponge loaded controlled release epicutaneous gel of lornoxicam. Applied Medical Research, 1 (1), 16-21. doi:10.5455/amr.20150127052147





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