Applied Medical Research. 2018;
5(2):(56-154)
Effect of camel milk supplementation in management of gastric ulcer
Aminu Lailaba Abubakar, Abdullahi Dandare, Shamsudeen Umar Dandare, Sulaiman Rabiu, Abdulqadir Sule Ibrahim, Saifullahi Armaya’u
Abstract
Background: Gastric ulcer is one of the major causes of morbidity globally. It is prevalent in Nigeria and more frequent among the lowest income group; this is primarily linked to their standard of living and constant use of non-steroidal anti-inflammatory drugs. The use of camel milk in the treatment of many diseases has long been established. Objective: This study was designed to evaluate the potentials of camel milk in the treatment of gastric ulceration. Methods: Albino rats weighed 120–150 g were divided into four groups of five rats each. Group I: negative control, group II: positive control, group III: ethanol-induced gastric ulcer rats supplemented with camel milk, group IV: ethanol-induced gastric ulcer rats orally dosed with omeprazole. Results: The results of this study revealed that white blood cells, red blood cells, HBC, pack cell volume, mean corpuscular volume, and platelets decreased significantly (P < 0.05) in ethanol-induced ulcer group compared to other groups. There were no significant differences (P > 0.05) in mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration level for all the groups investigated. The levels of antioxidant enzymes (catalase and superoxide dismutase) and vitamins (A, C, and E) were significantly improved toward normal (P < 0.05) due to camel milk supplementation. The histopathological analysis of the stomach tissue indicates preserved transmural architecture with clearly defined mucosa, submucosa, and muscularis propria in camel milk supplemented group and omeprazole treated group. Conclusion: These results demonstrated the potential use of camel milk in reversing the damaging effect of ethanol-induced gastric ulcer and alteration of some biochemical parameters. Hence, camel milk could be used as a dietary supplement for managing gastric ulcer
