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Applied Medical Research ISSN: 2149-2018
Applied Medical Research. 2018; 5(2):(55-120)


Potentiality of Crataeva nurvala bark in the management of thrombosis and membrane stabilization in the rural area, Bangladesh

Jalal Uddin, Farhina Rahman Laboni, Samira Karim, Zubair Khalid Labu

Abstract

Aim: Crataeva nurvala (C. nurvala) is a medicinally active plant, potentially used as traditional means of treating many health ailments such as prostatitis, prostate enlargement, inflammatory conditions, heart disease, thyroid and endocrine disorder, and urinary tract infection, respectively, in the rural region of Tangail, Jamalpur, Sherpur, and Barishal district since primitive era. In our concurrent research, the bark of this plant was undertaken in order to justify its folkloric history of thrombolytic, membrane stabilizing activity in vitro model, and for the quantification of total phenol content. Methods: The concentrated methanol extract partitioned into different fractions showed different amount of yield like 18.2 g of petroleum ether, 13 g of carbon tetrachloride, 11.1 g of chloroform, and 9.9 g of aqueous, respectively, then all of the fractioned extracts were employed to investigate folkloric uses of thrombolytic and membrane stabilizing potential in vitro models. Results: In the extrapolation of thrombolytic assay, petroleum ether fractioned exhibit the highest percent of clot lysis (27.36% ± 0.10%) activity compared with other fractioned and extract. Crude methanolic extract profoundly inhibited the breakdown of erythrocytes membrane (65.79% ± 0.40%)-induced by hypnotic solution and heat. On the other hand, acetylsalicylic acid (reference standard) resulted in 83.147% ± 0.39% inhibition of clot lysis. Alternatively, aqueous soluble fraction exposed slightly higher level of membrane stabilizing activity provoked by heat-induced hemolysis (75.3 ± 0.39). Conclusions: The present study was investigated to confirm the medicinal value of C. nurvala bark as a thrombolytic and membrane stabilizing agent.