Leukemia is a type of blood cancer in which blood stem cells develop abnormally and excessively in the bone marrow. Leukemia causes symptoms when abnormal white blood cells begin to replace healthy blood cells and spread. In addition to physical symptoms, such as pain, fatigue and shortness of breath, people with leukemia may also experience psychological symptoms such as depression or anxiety, as the disease alters the functioning of neurotransmitters and the Locus Coeruleus Locus, a brain nucleus involved, when dysfunctional in neurodegenerative diseases, in the control of the limbic system (memory, attention, concentration, control of anxiety and depression). This nucleus is directly or indirectly involved in the production of major neurotransmitters when it undergoes changes due to trigeminal input, it can determine the onset of psychiatric disorders, in particular depressive disorders and anxiety, panic attacks, experienced not only by the patient but also by the surrounding family context. Transcranial Magnetic Stimulation (TMS), together with neurophysiology, myofunctional therapy, posturology, psychiatry and psychotherapy, is included among the interventions that promote the development of the subject's neurotransmitters.