Development and characterization naproxen gel bearing eucalyptus oil for topical delivery
ikas ain, onika Thakur
Applied Medical Research. 2015;
Aim: Eucalyptus oil-based naproxen loaded gel system was developed for topical application on to the scalp in order to avoid the disadvantages associated with the oral administration of naproxen. Materials and Methods: Eucalyptus oil, propylene glycol, and Carbopol P-934 were used with different ratios in an attempt to develop topical gel formulations of naproxen. Eucalyptus oil also has the property to reduce inflammation and arthritis pain. The tropical gel containing naproxen was evaluated for appearance, homogeneity, gelling, pH, viscosity, spreadability and drug content. In-vitro diffusion studies of prepared gel formulations were carried out in phosphate buffer pH 6.8 using Francz diffusion cell. Results: The results of in-vitro drug release showed that the highest release (99.37% of drug released after 3 h) was from in formulation F3 containing Carbopol P-934 (1%) and eucalyptus oil (0.6 ml). Conclusion: The overall results of this study suggest that the F3 formula could be used in the preparation of naproxen gel containing eucalyptus oil as a topical dosage form to be used in the treatment of inflammation.