Background: Colorectal cancer (CRC) is a common malignancy in Jordan, it was the third most common cancer in male and female, it is curable if detected in early stage. Objectives: The objective was to study the epidemiological, clinical, and pathological features of CRC patients and analyzed the prognosis of this disease among our Jordanian patients in King Hussein medical city at Amman - Jordan. Materials and Methods: Retrospective cross-sectional study done at KHMC. Totally, 500 patients with proven diagnosed of CRC included in our study. A detailed clinical history was taken. And physical examination was performed. Clinicopathological data were collected and analyzed; histopathology report, management, and prognosis of these patients were also studied. Results: About 70% was colon cancer and 30% was rectal cancer, the mean age was 61 years, 55% were male, and 45 % were females, most common presenting symptom was abdominal pain. Only in 24 (2%) of patients diagnosed by routine screening program of CRC. In 90 patients (18%), they presented with metastatic disease, most common sites of metastasis was liver in 90%. The most common histopathology was adenocarcinoma. Adjuvant chemotherapy or chemoradiotherapy given in 320 patients, Median follow-up of patients post surgery was 45 months, during this period most of the patients developed recurrence of disease. Conclusion: we demonstrate advanced stage of presentation of this type of cancer, high probability of recurrence, and it significantly correlated with poor survival. Further investigation is required to fully understand pathology and prognosis of CRC.