The effect of the antioxidant drug “U-74389G” on acid phosphatase levels during ischemia reperfusion injury in rats
Constantinos Τsompos, Constantinos Panoulis, Konstantinos Τοutouzas, Aggeliki Triantafyllou, George Ζografos, Apostolos Papalois
Applied Medical Research. 2016;
Introduction: This experimental study examined the effect of the antioxidant drug “U-74389G”, on a rat model and particularly in an ischemia - reperfusion protocol. The effects of that molecule were studied biochemically using blood mean acid phosphatase (ACP) levels. Methods: 40 rats of mean weight 231.875 g were used in the study. ACP levels were measured at 60 min of reperfusion (groups A and C) and at 120 min of reperfusion (groups B and D). Administration of the drug U-74389G was predicted only for groups C and D. Results: U-74389G administration significantly decreased the ACP levels by 128.45% ±14.84% (p= 0.0000). Reperfusion time non-significantly decreased the ACP levels by 22.44% ± 25.86% (p= 0.2000). However, U-74389G administration and reperfusion time together significantly decreased the ACP levels by 74.45% ± 9.63% (p= 0.0000). Conclusions: U-74389G administration whether it interacted or not with reperfusion time, offers spectacular significant decreasing short – term effects on ACP levels.