E-ISSN 2149-2018
 

Original Research 


Determination of Minimum inhibitory concentrations of Common Biocides to Multidrug-Resistant Gram-negative bacteria

Rajendran Vijayakumar, Mohammad Saleh Al- Aboody, Meshal K. AlFonaisan, Wael Al Turaiki, Suresh Mickymaray, Premanathan Mariappan, Suliman A. Alsagaby, Tim Sandle.

Cited by (2)

Abstract
Background
Until now, very few studies have investigated the susceptibility profile of biocides to nosocomial pathogens and none reported in the Saudi Arabia. Hence, the aim of this study was to detect the minimum inhibitory concentrations (MIC) of a range of multidrug resistant (MDR) bacteria: Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae against three common hospital disinfectants: chlorhexidine, benzalkonium chloride and cetrimide.
Methods
The in vitro susceptibility tests of the three biocides were studied against 21 MDR A. baumannii, 11 MDR P. aeruginosa and 3 MDR K. pneumoniae strains, isolated from various clinical specimens in the Qassim region, Saudi Arabia. The susceptibility testing was performed by broth microdilution method following Clinical and Laboratory Standards Institute guidelines.
Results
Among 35 isolates tested, there was no reduced susceptibility observed in A. baumannii and K. pneumoniae, however, two isolates of P. aeruginosa were showed reduced susceptibility (> 512 g/mL) against benzalkonium chloride and cetrimide.
Conclusion
Our observations imply that reduced susceptibility was observed with quaternary ammonium compounds against P. aeruginosa and no apparent correlation exists between specific disinfectants and their multidrug resistance character in A. baumannii and K. pneumoniae. Further studies are required to confirm these results in terms of biocides resistance. <div style="display:none;"> <a href="http://escortbayanlara.com" target="_blank">antalya escort</a> </div>

Key words: Multidrug resistant Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae, Biocides, Benzalkonium chloride, quaternary ammonium compounds, disinfectant, nosocomial pathogens


 
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Lett Appl Microbiol 2018; (): .

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Distribution of biocide resistant genes and biocides susceptibility in multidrug-resistant Klebsiella pneumoniae , Pseudomonas aeruginosa and Acinetobacter baumannii — A first report from the Kingdom of Saudi Arabia
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How to Cite this Article
Pubmed Style

Rajendran Vijayakumar, Mohammad Saleh Al- Aboody, Meshal K. AlFonaisan, Wael Al Turaiki, Suresh Mickymaray, Premanathan Mariappan, Suliman A. Alsagaby, Tim Sandle. Determination of Minimum inhibitory concentrations of Common Biocides to Multidrug-Resistant Gram-negative bacteria. Appl Med Res. 2016; 2(3): 56-62. doi:10.5455/amr.20161012082036


Web Style

Rajendran Vijayakumar, Mohammad Saleh Al- Aboody, Meshal K. AlFonaisan, Wael Al Turaiki, Suresh Mickymaray, Premanathan Mariappan, Suliman A. Alsagaby, Tim Sandle. Determination of Minimum inhibitory concentrations of Common Biocides to Multidrug-Resistant Gram-negative bacteria. http://www.ejmamr.com/?mno=241032 [Access: December 15, 2018]. doi:10.5455/amr.20161012082036


AMA (American Medical Association) Style

Rajendran Vijayakumar, Mohammad Saleh Al- Aboody, Meshal K. AlFonaisan, Wael Al Turaiki, Suresh Mickymaray, Premanathan Mariappan, Suliman A. Alsagaby, Tim Sandle. Determination of Minimum inhibitory concentrations of Common Biocides to Multidrug-Resistant Gram-negative bacteria. Appl Med Res. 2016; 2(3): 56-62. doi:10.5455/amr.20161012082036



Vancouver/ICMJE Style

Rajendran Vijayakumar, Mohammad Saleh Al- Aboody, Meshal K. AlFonaisan, Wael Al Turaiki, Suresh Mickymaray, Premanathan Mariappan, Suliman A. Alsagaby, Tim Sandle. Determination of Minimum inhibitory concentrations of Common Biocides to Multidrug-Resistant Gram-negative bacteria. Appl Med Res. (2016), [cited December 15, 2018]; 2(3): 56-62. doi:10.5455/amr.20161012082036



Harvard Style

Rajendran Vijayakumar, Mohammad Saleh Al- Aboody, Meshal K. AlFonaisan, Wael Al Turaiki, Suresh Mickymaray, Premanathan Mariappan, Suliman A. Alsagaby, Tim Sandle (2016) Determination of Minimum inhibitory concentrations of Common Biocides to Multidrug-Resistant Gram-negative bacteria. Appl Med Res, 2 (3), 56-62. doi:10.5455/amr.20161012082036



Turabian Style

Rajendran Vijayakumar, Mohammad Saleh Al- Aboody, Meshal K. AlFonaisan, Wael Al Turaiki, Suresh Mickymaray, Premanathan Mariappan, Suliman A. Alsagaby, Tim Sandle. 2016. Determination of Minimum inhibitory concentrations of Common Biocides to Multidrug-Resistant Gram-negative bacteria. Applied Medical Research, 2 (3), 56-62. doi:10.5455/amr.20161012082036



Chicago Style

Rajendran Vijayakumar, Mohammad Saleh Al- Aboody, Meshal K. AlFonaisan, Wael Al Turaiki, Suresh Mickymaray, Premanathan Mariappan, Suliman A. Alsagaby, Tim Sandle. "Determination of Minimum inhibitory concentrations of Common Biocides to Multidrug-Resistant Gram-negative bacteria." Applied Medical Research 2 (2016), 56-62. doi:10.5455/amr.20161012082036



MLA (The Modern Language Association) Style

Rajendran Vijayakumar, Mohammad Saleh Al- Aboody, Meshal K. AlFonaisan, Wael Al Turaiki, Suresh Mickymaray, Premanathan Mariappan, Suliman A. Alsagaby, Tim Sandle. "Determination of Minimum inhibitory concentrations of Common Biocides to Multidrug-Resistant Gram-negative bacteria." Applied Medical Research 2.3 (2016), 56-62. Print. doi:10.5455/amr.20161012082036



APA (American Psychological Association) Style

Rajendran Vijayakumar, Mohammad Saleh Al- Aboody, Meshal K. AlFonaisan, Wael Al Turaiki, Suresh Mickymaray, Premanathan Mariappan, Suliman A. Alsagaby, Tim Sandle (2016) Determination of Minimum inhibitory concentrations of Common Biocides to Multidrug-Resistant Gram-negative bacteria. Applied Medical Research, 2 (3), 56-62. doi:10.5455/amr.20161012082036





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